These restrictions apply to the ability of the device to boot a Mac, any of these devices are suitable for general backup. See the Preparing a hard drive for use with Carbon Copy Cloner and What makes a volume bootable? sections of the CCC documentation for more information on disk formatting and partitioning. PowerPC Macs can only boot from a hard drive partitioned with the APM partitioning scheme. In general, only Intel-based Macs can boot from USB hard drives. For an T2 Mac, start up your Mac and meanwhile, press down Command - Option/Alt - R together until seeing the spinning globe appears on the screen. iPods are not recommended for general use as a bootable drive, and USB-based iPods may not boot every model of Macintosh. Change the startup security settings to allow Mac start up from a USB: Boot your T2 Intel-based Mac or M1 Mac in Recovery Mode. Check with the manufacturer of your hard drive enclosure to verify that booting from the enclosure is explicitly supported. * Not all Firewire and USB hard drive enclosures are capable of booting Mac OS X. Choose your USB flash drive and let Disk Drill make it bootable for you. Choose the macOS Monterey installer file by clicking the Add macOS installer button and choosing the Locate installer on disk option. Launch Disk Drill from Applications and select the macOS Installer option from the left pane. I guess you know more than the people at Carbon Copy Cloner. Connect a suitable USB flash drive to your Mac. Last night I made a clone on my G4, with Carbon Copy with USB, and two different pop up windows warned me that I couldnt boot with USB.